Online Sample Preparation

The Co-Sense series features automatic sample processing systems intended to improve the efficiency of LC-NMR and LC-MS operations by automating complicated sample processing steps. This eliminates the need for tedious, time-consuming, and expensive manual processes. It also achieves parameter settings for separating target components by HPLC can be set freely without being encumbered by LC-NMR or LC-MS limitations. The Co-Sense series is especially well suited to the structural analysis of impurities in pharmaceuticals. It is also advantageous for NMR measurement in the life sciences or chemical industry fields, such as to research metabolites in biological organisms or to analyze the side reaction in chemical synthesis.
 

Full Automation of Sample Processing

 

All sample processing steps are automated, from introducing the sample, purifying target components, concentrating, and desalting, to solvent replacement and collecting fractions in NMR sample tubes or delivering the sample to an LCMS system. Consequently, it not only increases productivity, but also eliminates operator errors inherent in manual processes. Also, since samples are processed serially online, even unstable samples can be measured reliably.
 

Improved Measurement Sensitivity

 

Because target components can be concentrated to levels several times to several tens of times that of conventional LC-NMR and LC-MS systems, NMR and MS spectra with high S/N ratios can be obtained in a short time and measurement throughput is increased.
 

Optimized HPLC Conditions

 

Since separation by HPLC is not dependent on NMR measurements, optimal separation parameters can be specified. Therefore, there is no need to evaluate parameters based on NMR considerations. This reduces the amount of work involved in setting parameters.
 

Easier to Operate

Systems are controlled using software with a graphical user interface. This makes the software easy to operate and allows confirming the system operating status at a glance.
 

Reduced Solvent Consumption

 

The Co-Sense for LC-NMR system uses normal inexpensive solvents for fractionation processes, which can consume large amounts of solvent. In contrast, it uses only small amounts of expensive deuterated solvents, which contributes to operating cost reduction.
The name "Co-Sense" means a collaboration of senses, which is the concept of the product. It represents the user and manufacturer working together to create new value.

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