CI and CI/NCI Measurement

 

Featuring New Functionality for Analyzing Unknown or Ultra-Trace Components

Models with CI/NCI Can Switch Automatically Between EI, CI, and NCI Ionization Methods

 

CI

Since information about molecular weight can be obtained easily using chemical ionization (CI), accurate qualification is possible.

When analyzing mass spectra, first molecular ions are determined. Then, once molecular ions are determined, the subsequent data analysis is easy. However, when using electron ionization (EI), in some cases no molecular ions are detected or they are difficult to confirm due to relatively weak intensity. In contrast, since CI is a softer ionization method than EI, fragmentation is less likely to occur, so information about molecular weight is more readily obtained. 

Because the GCMS-QP2010 Ultra can measure a broad mass range, up to a maximum m/z value of 1090, it can easily measure molecular ions even for components with large molecular weights, such as TMS derivatives of saccharose (see below).

 

 
 
 
 
 
 
 
 
 
TMS Derivatives of Saccharose (mass spectra of C36H86O11Si8 at MW = 918)

Molecular weight ions (+NH4) can be detected using CI, even when they cannot be detected using EI.
 

NCI

Negative chemical ionization (NCI) or negative ion chemical ionization (NICI) enables selectively measuring, with ultra high sensitivity, chemical substances with an electron affinity, such as chlorine-based compounds.

Environmental analysis requires measuring ultra-trace amounts of chemical substances such as endocrine disruptors. Highly toxic pollutants contain large numbers of chlorine-based compounds, such as persistent organic pollutants (POPs), which are monitored according to the Stockholm Convention. NCI is ideal for quantitating trace quantities of such compounds. Even for compounds without electron affinity, such as estradiol, electron affinity can be introduced using derivatization to enable highly sensitive measurement by NCI.
10 fg ß-Estradiol (SIM)

10 fg ß-Estradiol (SIM)

 
 
 
R^2 = 0.9999212
 
R = 0.9999606
 

Calibration Curve for 10 fg to 1 pg

 

 

Calibration Curve for 10 fg to 1 pg

 

 

 

PFB and TMS Derivatization of ß-Estradiol

PFB and TMS Derivatization of ß-Estradiol

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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