Autosampler

 

Nexera X2 Series

 

SIL-30ACMP

The SIL-30ACMP achieves an ultrafast injection performance exceeding that of current models while maintaining ultralow carryover performance. In addition, up to 6 microtiter plates can be loaded, enabling a maximum of 2304 samples to be analyzed continuously. By incorporating these various functions,  the Nexera MP which includes the SIL-30ACMP is ideally suited as a front-end LC for LC/MS and LC/MS/MS systems.

 

 

 

 

 

 

 

SIL-30AC Autosampler

The total-volume injection SIL-30AC autosampler features a pressure tolerance of 130 MPa as well as the world’s fastest sample injection (10 seconds), which dramatically reduces the total cycle time. It includes auto pretreatment and overlapping functions as standard, and an optional loop-injection method configuration to minimize delay volume. With reduction of the needle contact area, special coatings, surface treatments, and a new needle seal, the SIL-30AC reaches a new level of low carryover performance, which is especially beneficial for LCMSMS analysis. In addition, the included sample cooler features a dehumidifier function for storing samples at a constant temperature between 4 °C and 40 °C.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
The rackchanger unit replaces the microplates on autosampler racks to enable samples to be continuously analyzed. It allows loading up to 12 microplates inside the unit (maximum 4608 samples). Samples can be temperature-controlled with a block heating/cooling system (with dehumidifier function and 4 °C to 40 °C range) not only to refrigerated temperatures, but also to stable temperature levels near room temperature.

 

 

 

 

 

 

 

 

Nexera XR Series

 

SIL-20AXR/SIL-20ACXR Autosampler 

The SIL-20AXR is a total volume injection type (direct injection) autosampler that, in addition to a high-speed injection function and high-precision function for injecting trace quantities, features an improved high-pressure valve that increases the pressure resistance (max. allowable pressure: 66 MPa). The internal volume of the high-pressure valve was reduced to suppress sample diffusion, which is especially suited to high separation analysis. The 20ACXR includes a sample cooler that allows samples in sample racks to be stored at a constant temperature between 4 °C and 40 °C.

 
 
 
 
 
 
 
 
 
 
 

 

 

 

 

Method Variable sample injection volume and total volume direct injection
Allowable Operating Pressure 66 MPa
Injection Volume Range 0.1 µL to 50 µL (0.1 µL to 100 µL with option)
Number of Samples Processed 175 (1-mL vials), 105 (1.5-mL vials, 70 for 20AC), 50 (4-mL vials), 192 (two 96-well MTP/DWP), 768 (two 384-well MTP/DWP)
Besides these, ten 1.5-mL vials can be used
Injection Volume Precision Max RSD 0.3 % (normally max 0.2 %: depending on specified conditions)
Cross-Contamination Max 0.005 % (depending on specified conditions, without rinsing, normally max 0.0035 %)
Needle Rinsing Freely settable, before or after sample injection
Operational Temp. Range 4 - 35 °C

 

 

 

Prominence Series


SIL-20A/20AC Autosampler

 

 The SIL-20A is a total volume injection type (direct injection) autosampler that  enables high-speed injection and multi-analyte processing. Materials used in needle, valve, and other flow lines were closely considered and a needle rinsing function is provided to carefully minimize cross-contamination (carryover), which is especially useful for high-precision LC-MSMS analysis. The SIL-20AC includes a sample cooler that features a dehumidifier function for storing samples at a constant temperature between 4 °C and 40 °C.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

The rackchanger unit exchanges the microplates on autosampler racks to enable samples to be continuously analyzed. 12 plates can be mounted inside the main unit and stored under refrigerated conditions.

 
 

 

 

 

 

 

Method Variable sample injection volume and total volume direct injection
Injection Volume Range 0.1 µL to 100 µL (0.1 µL to 2000 µL with option)
Number of Samples Processed 175 (1-mL vials), 105 (1.5-mL vials), 50 (4-mL vials),
192 (two 96-well MTP/DWP), 768 (two 384-well MTP/DWP)
*Twelve 96-well MTP/DWP in the rackchanger
Injection Volume Precision Max RSD 0.3 % (under specified conditions)
Cross-Contamination Max 0.005 % (naphthalene and chlorhexidine)
Needle Rinsing Freely settable, before or after sample injection

 

 

SIL-10AF/P Autosampler

This is a multi-purpose model capable of large injection volumes. It is particularly well suited to automatic pretreatment applications, such as dilution and mixing processes using auto injectors. The SIL-10AF offers higher sample injection speeds than the previous SIL-10A model (reduced to 1/3 of previous) It can accommodate two 96-well microplates.

The standard SIL-10AP can inject large volumes up to 5 mL. Use it for semi-preparative processing as well.

* A CBM-20A or SCL-10AVP (version 5.40 or later) controller is required to use the SIL-10AF/10AP. CLASS-VP version 6.1 or later is required to control it via the workstation. An SIL-10A upgrade kit (228-40811-91) is required to upgrade model SIL-10A to SIL-10AF. To upgrade model SIL-10AP to SIL-10AF, an SIL-10A upgrade kit, together with 5-mL syringe with mounting bracket, 5-mL sample loop, fractioning stator, fractioning rotor, and an LL rack (compatible with 13-mL vials) are required.

 

 

 

 

 

 

 

 

 

Comparison for Autosampler Selection Autosamplers can be selected according to objectives.

 

Model Name Features/Applications Injection Volume (µL) Number of Vials Microplate
Capacity
Main Liquid
Contact Surface Materials
SIL-20AXR In addition to high-speed injection and high-precision functions for trace volume injection, this model features excellent pressure resistance (max allowable pressure: 66 MPa ). The internal volume of the high-pressure valve was reduced to suppress sample diffusion. (direct injection, specialized needle coating, and reinforced PEEK rotor) 0.1 to 50 (max 100) 175 (1 mL), 105/70 (1.5 mL), 50 (4 mL) Cools max two 96/384-well plates PEEK, (SS)
SIL-20A Outstanding reproducibility and accuracy for trace volume injection. A needle rinsing function is included standard to minimize cross-contamination (carryover). It also allows high speed injection. (direct injection, specialized needle coating, and PEEK rotor) 0.1 to 100 (max 2000) 175 (1 mL), 105/70 (1.5 mL), 50 (4 mL) Cools max two 96/384-well
plates
PEEK, (SS)
SIL-HT Designed for multianalyte high-speed analysis. It also offers extremely low cross-contamination. (direct injection, specialized needle coating, and PEEK rotor) 0.1 to 100 (max 2000) 350 (1 mL), 210/140 (1.5 mL),
100 (4 mL)
Cools max four 96/384-well plates PEEK, (SS)
SIL-10AF Enables using loop metering method (or syringe metering method) for injection. In addition, since pretreatment using an autosampler is performed at a high speed, this is well suited to dilution and mixing. Suited to cases where cost is priority. 1 to 50 (max 5000) 100 (1.5 mL),
80 (4 mL)
Accommodates two 96-well plates SS
SIL-10AP Injection capability up to 5 mL is included standard. Well suited for semi-preparative, GPC cleanup, and concentration system applications. 1 to 5,000 100 (1.5 mL),
80 (4 mL),
25 (13 mL)
Accommodates two 96-well plates SS
SIL-10Ai Flow lines are made of PEEK, which is resistant to hydrochloric acid and halogens. This model is suited to applications where such eluent is likely to be used. 1 to 50 (max 250) 100 (1.5 mL),
80 (4 mL)
None PEEK
 
 
Manual Injectors
7725/7725i,
8125 (semi-micro),
9725/9725i (PEEK)
3725i (Preparative)

 

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