Combining the simplicity of MALDI, the power of MSⁿ, and the accuracy and resolution of TOF, the AXIMA Resonance provides researchers a unique solution to the next generation of structural and sequencing challenges. Designed without compromise, the AXIMA Resonance features high mass resolution and mass accuracy across MS and MSⁿ analyses, excellent precursor ion selection, variable energy CID control on the fly, and outstanding sensitivity to ensure confident, high-quality results across a range of applications.

• Advanced MSⁿ Performance - The unique combination of MALDI and QIT allows generation of ions using a number of different matrices; switching between positive and negative ionization modes in seconds; simple high resolution precursor ion selection for MSn experiments, and controllable MSn fragmentation.

Incorporating a TOF analyzer promotes high resolution and high mass accuracy for all ions generated regardless of their origin.

• Excellent Precursor Ion Selection - Allows ions from complex mixtures or closely associated neighboring isotopic envelopes to be easily isolated and subsequently fragmented; trapping resolution greater than 1000 FWHM permits the analysis of samples with similar nominal mass

Key Resonance Features

• High Sensitivity/Resolution - Near axis laser irradiation provides enhanced ion transmission and sensitivity in all modes of operation, while an uncompromised design ensures highly efficient trapping functionality.
• Low Sample Consumption - Allows many more MS/MS experiments to be performed on the same sample spot.
• Unparalleled Flexibility - Not just another proteomics workhorse, polymers, oligonucleotides, SNPs, metabolites, carbohydrates and small molecules, among others, may all be analyzed and processed. It is suitable with most common MALDI matrices, and a variety of sample target formats, including standard microtiter plate format and microscope slide design targets, can be used.
• Seamless Integration with Other Instruments - Like all AXIMA MALDI-TOF systems, the AXIMA Resonance can be fully integrated with robotic sample preparation devices, including the AccuSpot MALDI plate spotter and CHIP chemical printer, to create application-specific platforms. Integration with the CHIP creates a powerful platform for tissue imaging, while using an AXIMA instrument with a Prominence GPC system and AccuSpot results in a fully automated platform for polymer analysis that delivers quick, detailed analysis of ultra-trace substances.

The AXIMA Resonance can also be combined with various fractionation/enrichment chemistries and Nonlinear Dynamic’s Progenesis biomarker software for a complete, integrated biomarker discovery solution.

Software

Intuitive software incorporating data-dependent workflows facilitates the seamless analysis of as few or as many samples as required and achieves the maximum result with minimal user input, making it ideal for novice and expert users alike. A number of application-centric software suites empower researchers and aid investigation. These include:

• Proteomics - Intellimarque^TM software provides automated data-dependent peptide mass fingerprinting and MS/MS of peptides with optional incorporated Mascot database searching
• LC-MALDI - Allows the fully automated acquisition of LC separated samples deposited onto MALDI targets and the subsequent identification of proteins via MS/MS of the peptides detected
• Post Translational Modification Investigation - PTM Finder^TM software permits researchers to use data mining to determine previously undetected peptide modifications.
• Tissue Imaging - Integration with the CHIP-1000 chemical printer allows automated acquisition of data and interrogation using proprietary visualization software or automated export to BioMap

Support

AXIMA systems are fully supported throughout their lifetime using sophisticated Web-based service diagnostics and the capability of real-time remote monitoring. A wide range of service contracts are available, catering to all budgets and requirements, including IQ/OQ environments.